Láminas 41-50

Dev107714 41..50

Genetic data indicate that abrogation of Notch-Rbpj or Wnt-β-catenin pathways results in the loss of the intestinal stem cells (ISCs). However, whether the effect of Notch is direct or due to the aberrant differentiation of the transit-amplifying cells into post-mitotic goblet cells is unknown. To address this issue,we havegenerated composite tamoxifen-inducible intestine-specific genetic mouse...

ConnCensus Vol. 50 No. 41

41-Azido-41-de­oxy­rapamycin

The title compound, C(51)H(78)N(4)O(12), is a derivative of rapamycin, a triene macrolide anti-biotic mol-ecule isolated from Streptomyces hygroscopicus. The macrocyclic ring structure has 15 chiral centres, with one of the substituent hy-droxy groups giving an intra-molecular hydrogen bond to a ketone O-atom acceptor. The mol-ecules also form inter-molecular hy-droxy-ketone O-H⋯O hydrogen-bond...

Rev_iss_web_ene_13036_23-7 41..41

G. S. Collins and Y. Le Manach Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK, and Departments of Anesthesia and Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, Population Health Research Institute, McMaster University and the Perioperati...

as tr o - ph / 9 50 81 41 29 A ug 1 99 5 Intracluster Globular

Globular cluster populations of supergiant elliptical galaxies are known to vary widely, from extremely populous systems like that of UGC 9799, the centrally dominant galaxy in Abell 2052, to globular-cluster-poor galaxies such as NGC 5629 in Abell 2666. Here we propose that these variations point strongly to the existence of a population of globular clusters that are not bound to individual ga...